I talk about this more in the narrative of the video I posted yesterday, but I think there are four or five players who really stand out based on Opening Day 2009 matchups if you're playing in daily contests. Particularly in heads up live drafts, you'll want to focus on getting these guys, and wait to pick players at other positions where the gap between #1 and #2 isn't likely to be as large. Keep in mind that in some cases, we don't know for sure who the opening day starters are going to be, so there's some guesswork involved.
In any case, the four guys who seem to have a clear advantage over others at their positions are:
1. Grady Sizemore
2. Victor Martinez
3. David Wright
4. Ian Kinsler
While I haven't actually set up my spreadsheet to do the calculations yet, they look like clear standouts, based on likely opposing pitchers, ballpark, and ability.
At most other positions there are at least two good options - Sabathia/Peavy, Pujols/Teixeira, Ramirez/Reyes, lots of relief pitchers. In an heads up, live draft contest if you can get all four of those you'll be in good shape.